What we do
Three kinds of work, one way of working. We understand your problem, run the analysis it needs, build whatever does not already exist, and deliver results you own outright.
Protein and enzyme engineering
Making a protein do something it does not currently do.
What clients bring us
- Activity lost at process temperature, pH or in solvent
- Poor expression, or aggregation once expressed
- A chimera or fusion that will not fold
- Specificity that has to shift without losing activity
- A need for a tougher starting scaffold than the one they have
Antibody discovery support
Deciding which candidates deserve bench time, and which will fail later for reasons already visible now.
What clients bring us
- More candidates than there is budget to test
- Developability liabilities in a promising lead
- A humanisation step that must not cost affinity
- Epitope and paratope questions
Applied machine learning for experimental data
Turning instrument output into answers you can act on.
What clients bring us
- Spectroscopic data, including Raman
- Sequencing and assay output
- A property that needs predicting from sequence
- Pharmacokinetic behaviour of biologics
How we work
Four steps, every project
We understand the problem first
Before anything is proposed we need to know what the protein has to do, what you have already tried, and what a good outcome looks like to you. This is a conversation, not a questionnaire.
We suggest and run the analysis it needs
We tell you which methods can answer your question and which cannot. If computation cannot answer it, we say so rather than selling you an analysis that will not help.
If the right tool does not exist, we build it
Much of what we use was built for a specific client problem. When nothing suitable exists for yours, we build what does, meeting your requirement exactly rather than bending your question to fit existing software.
We deliver the results, and you own them
We work through the results with you rather than handing something over and leaving. You own the IP.
What it costs
A fixed hourly rate, agreed before we start. No hidden charges.
The first conversation is free.
No minimum and no maximum: no job is too big or too small.
What we need from you
- The sequence or construct, and what it has to do
- Any data you already have, including the attempts that failed
- Someone we can put questions to
Confidentiality
We work under your NDA, or ours if you would rather. Your project is not discussed or shown anywhere else.
Ownership
You own the results, completely.
We take no stake in your molecule and retain no rights to what we produce for you.
Tell us the problem
A sentence or two is enough to start. You will be talking to the people who would solve it.
Describe your problem